Fig. 6

Treatment with δ-secretase inhibitor 11 restored MAP-2 and synapse-associated protein expression in SAMP8 mice. a Immunostaining of the neuronal marker MAP-2 in the cortex and hippocampus. Arrows indicate neuronal soma and dendrites stained by MAP-2. b, c MAP-2 immunoreactivity was illustrated as the percent area of the neuropil in the cortex and hippocampus of SAMP8 mice. *P < 0.05, unpaired Student’s t-test, n = 5 mice per group. d, e Western blot analysis of brain lysate showing the expression of postsynaptic density protein 95 (PSD-95) and synaptophysin (SYP) in the two groups. *P < 0.05 between groups, unpaired Student’s t-test; n = 6 mice per group