Exploring the regulatory roles of circular RNAs in Alzheimer’s disease

Table 1 Summary of Alzheimer’s disease-related circRNAs

Gene	Expression	Function	Target gene/expression	Source	References
circ_0000950	NS	miRNA sponges	miR-103 ↓	PC12 cells and cerebral cortical neurons induced by Aβ_1–42	[40]
mmu_circRNA_013636	Upregulated	–	Unknown	Hippocampal tissues of SAMP8 AD mice	[41]
mmu_circRNA_012180	Downregulated	–	Unknown	Hippocampal tissues of SAMP8 AD mice	[41]
ciRS-7	Downregulated	miRNA sponges	miR-7 ↑	Brain tissues of AD patients	[42,43,44]
circHDAC9	Downregulated	miRNA sponges	miR-138 ↑	Sera of AD patients and hippocampal tissues of AD mice	[45]
circRNA KIAA1586	–	miRNA sponges	miR-29b, miR-101, miR-15a	Four gene expression profiles of AD from the Gene Expression Omnibus (GEO) database	[46]
circHOMER1	–	miRNA sponges	miR-651	Cortex of AD patients	[13]
circCORO1C	–	miRNA sponges	miR-105	Cortex of AD patients	[13]
circNF1–419	Upregulated	Interact with proteins	Dynamin-1 ↑/AP2B1 ↑	Senescent cell model induced by D-galactose	[47]
mmu_circ_017963	Downregulated	–	mmu_miR_7033-3p	Hippocampal tissues of SAMP8 AD mice	[48]

ISSN: 2047-9158